Sorting out the new HSV type specific antibody tests

Sex Transm Infect. 2001 Aug;77(4):232-7. doi: 10.1136/sti.77.4.232.


This review will delineate performance characteristics and limitations, as far as they are known, of the new glycoprotein G based, type specific HSV serologies. Several of these tests have been FDA approved in the United States for use in adults. With the departure of Gull/Meridian from the HSV serology market, it is important for clinicians to understand the sources and claims of the remaining type specific tests. Moreover, inaccurate tests using crude antigen preparations remain on the market. These tests are identified based on product insert information provided by company representatives.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibody Specificity*
  • Benchmarking
  • Blotting, Western
  • Child
  • Child, Preschool
  • Cross Reactions / immunology
  • Drug Approval
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Herpes Genitalis / diagnosis*
  • Herpes Genitalis / transmission
  • Herpes Simplex / diagnosis*
  • Herpes Simplex / transmission
  • Herpesvirus 1, Human / immunology*
  • Herpesvirus 2, Human / immunology*
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Point-of-Care Systems / standards
  • Pregnancy
  • Reagent Kits, Diagnostic / standards*
  • Sensitivity and Specificity
  • Viral Envelope Proteins


  • Reagent Kits, Diagnostic
  • Viral Envelope Proteins
  • glycoprotein G, herpes simplex virus type 2