Absence of Human herpesvirus-6 Genome by Polymerase Chain Reaction in Children With Hodgkin Disease: A Children's Cancer Group Lymphoma Biology Study

J Pediatr Hematol Oncol. Jun-Jul 2001;23(5):282-5. doi: 10.1097/00043426-200106000-00009.


Background: Human herpesvirus-6 (HHV6) has been implicated in adult lymphomas but the role that HHV6 has in lymphomagenesis is unclear. Because primary infection occurs in children, a prospective study was undertaken to detect HHV6 in those with pediatric Hodgkin disease (HD).

Observations: Tumor was obtained from children with HD entered on a Children's Cancer Group Biology Study. Polymerase chain reaction (PCR) was performed using HHV6 primers. All 47 specimens (40 nodular sclerosing; 3 lymphocyte predominant; 3 mixed cellularity; and 1 unclassified) were negative for HHV6.

Conclusions: The results demonstrate no HHV6 sequence in childhood HD.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child
  • DNA, Neoplasm / analysis
  • DNA, Viral / isolation & purification*
  • Herpesvirus 6, Human / isolation & purification*
  • Hodgkin Disease / pathology
  • Hodgkin Disease / virology*
  • Humans
  • Polymerase Chain Reaction
  • Sensitivity and Specificity


  • DNA, Neoplasm
  • DNA, Viral