This paper analyzes B-spline interpolation techniques of degree 2, 4, and 5 with respect to all criteria that have been applied to evaluate various interpolation schemes in a recently published survey on image interpolation in medical imaging (Lehmann et al., 1999). It is shown that high-degree B-spline interpolation has superior Fourier properties, smallest interpolation error, and reasonable computing times. Therefore, high-degree B-splines are preferable interpolators for numerous applications in medical image processing, particularly if high precision is required. If no aliasing occurs, this result neither depends on the geometric transform applied for the tests nor the actual content of images.