Microtubule motors, phosphorylation and axonal transport of neurofilaments

J Neurocytol. Nov-Dec 2000;29(11-12):873-87. doi: 10.1023/a:1010951626090.

Abstract

The recent demonstration that the axonal transport motors kinesin and dynein participate in axonal transport of neurofilaments (NFs), and that the association of NFs with these motors is regulated by phosphorylation provides new insight into several aspects of axonal transport and NF biology. This review juxtaposes older and more recent findings on NF dynamics, and speculates on the organization of axonal NFs as suggested by real-time analyses of NF transport.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Axonal Transport / physiology*
  • Dyneins / metabolism
  • Kinesin / metabolism
  • Microscopy, Fluorescence
  • Microtubules / metabolism*
  • Molecular Motor Proteins / metabolism*
  • Neurodegenerative Diseases / metabolism
  • Neurofilament Proteins / genetics
  • Neurofilament Proteins / metabolism*
  • Neurons / cytology
  • Neurons / metabolism*
  • Phosphorylation
  • Protein Subunits
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism
  • Retina / metabolism

Substances

  • Molecular Motor Proteins
  • Neurofilament Proteins
  • Protein Subunits
  • Recombinant Fusion Proteins
  • Dyneins
  • Kinesin