Marijuana in the management of amyotrophic lateral sclerosis

Am J Hosp Palliat Care. Jul-Aug 2001;18(4):264-70. doi: 10.1177/104990910101800411.


Marijuana has been proposed as treatment for a widening spectrum of medical conditions. Marijuana is a substance with many properties that may be applicable to the management of amyotrophic lateral sclerosis (ALS). These include analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction. In addition, marijuana has now been shown to have strong antioxidative and neuroprotective effects, which may prolong neuronal cell survival. In areas where it is legal to do so, marijuana should be considered in the pharmacological management of ALS. Further investigation into the usefulness of marijuana in this setting is warranted.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Amyotrophic Lateral Sclerosis / complications
  • Amyotrophic Lateral Sclerosis / drug therapy*
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Amyotrophic Lateral Sclerosis / psychology
  • Cannabis / therapeutic use*
  • Drug and Narcotic Control / legislation & jurisprudence
  • Evidence-Based Medicine
  • Humans
  • Patient Selection
  • Phytotherapy*
  • Treatment Outcome