Oxygen effects on glucose measurements with a reference analyzer and three handheld meters

Diabetes Technol Ther. 2000 Autumn;2(3):349-62. doi: 10.1089/15209150050194215.


Oxygen may affect glucose meter and reference analyzer measurements. We evaluated the effects of changes in blood oxygen tension (Po2) on Accu-Chek Comfort Curve (Roche Diagnostics, Indianapolis, IN), Precision G, (Abbott Laboratories, Bedford, MA) and One Touch II (Lifescan, Milpitas, CA) glucose meter measurements, and on Yellow Springs Instruments (YSI) (Yellow Springs, OH) reference analyzer measurements. Venous blood drawn from healthy volunteers was adjusted to three glucose levels of 80, 200, and 400 mg/dL, each tonometered with six different Po2 levels (40, 80, 160, 240, 320, and 400 torr). To quantitate oxygen effects on reference analyzer measurements, glucose differences between test sample (Po2 changed) and control (Po2 80 torr) were calculated (YSItest-YSIcontrol). The threshold for determination of oxygen effects was +/-2 SD, where 2 SD was fro

Publication types

  • Comparative Study

MeSH terms

  • Blood Chemical Analysis / instrumentation*
  • Blood Chemical Analysis / methods
  • Blood Glucose / analysis*
  • Critical Illness
  • Humans
  • Oxygen / blood*
  • Partial Pressure
  • Point-of-Care Systems / standards*
  • Reference Values
  • Reproducibility of Results


  • Blood Glucose
  • Oxygen