Wnt signaling and mammary tumorigenesis

J Mammary Gland Biol Neoplasia. 2001 Jan;6(1):37-52. doi: 10.1023/a:1009564431268.


Wnt expression patterns during mammary development support a role for Wnts in breast development and in mammary epithelial responses to systemic hormones. The deregulation of Wnt signaling also plays a role in breast cancer. Activation of the Wnt signaling pathway is a major feature of several human neoplasias and appears to lead to the cytosolic stabilization of a transcriptional co-factor, beta-catenin. This co-activator can then regulate transcription from a number of target genes including the cellular oncogenes cyclin D1 and c-myc. This review will summarize the current state of knowledge of Wnt signal transduction in a range of model systems and will then address the role of Wnts and Wnt signaling in mammary development and cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Female
  • Humans
  • Mammary Neoplasms, Animal / metabolism*
  • Proto-Oncogene Proteins / metabolism*
  • Signal Transduction / physiology*
  • Wnt Proteins
  • Zebrafish Proteins*


  • Proto-Oncogene Proteins
  • Wnt Proteins
  • Zebrafish Proteins