Comparative analysis of HD2 type histone deacetylases in higher plants

Planta. 2001 Jun;213(2):280-5. doi: 10.1007/s004250000506.


Zea mays (L.) histone deacetylase HD2 was identified as a new type of histone deacetylase (HDAC) unrelated to the well-known Rpd3p and Hdalp families but with sequence homology to peptidyl-prolyl cis-trans isomerases (PPIases). Here we show that HD2 is a multigene family with highly related members in various plant species. Gene analysis revealed a similar exon/intron structure in Arabidopsis thaliana (L.) Heynh. and Z. mays, and most of the sequences analyzed were demonstrated to possess an intron of the very rare AT-AC type.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis / enzymology*
  • Arabidopsis / genetics
  • Expressed Sequence Tags
  • Histone Deacetylases / metabolism*
  • Introns
  • Molecular Sequence Data
  • Multigene Family
  • Oryza / enzymology*
  • Oryza / genetics
  • Peptidylprolyl Isomerase / genetics
  • Peptidylprolyl Isomerase / metabolism
  • Sequence Homology, Amino Acid
  • Zea mays / enzymology*
  • Zea mays / genetics


  • Histone Deacetylases
  • Peptidylprolyl Isomerase