Polymorphic exocellular protease expression in clinical isolates of Trichophyton tonsurans

Mycopathologia. 2001;150(3):117-20. doi: 10.1023/a:1010977014536.


Tinea capitis continues to be an overwhelmingly prevalent disease in children. Despite the fact that it was recognized over a century ago, the factors that dictate the divergent clinical presentations seen with tinea capitis (e.g., carrier state, chronic non-inflammatory infection, acute severely-inflammatory infection) remain unknown. Given the pathogenic role of exocellular proteases in dermatophyte infections and their potential immunogenic role, this investigation was designed to characterize strain-specific variability in fungal protease expression and activity in Trichophyton tonsurans isolates identified from children with tinea capitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Collagenases / biosynthesis
  • Endopeptidases / biosynthesis*
  • Endopeptidases / classification
  • Humans
  • Pancreatic Elastase / biosynthesis
  • Peptide Hydrolases / biosynthesis
  • Tinea Capitis / microbiology*
  • Trichophyton / enzymology*
  • Trichophyton / isolation & purification


  • Endopeptidases
  • Peptide Hydrolases
  • keratinase
  • Pancreatic Elastase
  • Collagenases