Polymers in drug delivery

Curr Opin Chem Biol. 2001 Aug;5(4):447-51. doi: 10.1016/s1367-5931(00)00227-1.

Abstract

Advances in polymer science have led to the development of several novel drug-delivery systems. A proper consideration of surface and bulk properties can aid in the designing of polymers for various drug-delivery applications. Biodegradable polymers find widespread use in drug delivery as they can be degraded to non-toxic monomers inside the body. Novel supramolecular structures based on polyethylene oxide copolymers and dendrimers are being intensively researched for delivery of genes and macromolecules. Hydrogels that can respond to a variety of physical, chemical and biological stimuli hold enormous potential for design of closed-loop drug-delivery systems. Design and synthesis of novel combinations of polymers will expand the scope of new drug-delivery systems in the future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biodegradation, Environmental
  • Drug Carriers*
  • Drug Delivery Systems*
  • Polymers*

Substances

  • Drug Carriers
  • Polymers