Stronger suppression of plasma cholesterol and enhancement of the fecal excretion of steroids by a buckwheat protein product than by a soy protein isolate in rats fed on a cholesterol-free diet

Biosci Biotechnol Biochem. 2001 Jun;65(6):1412-4. doi: 10.1271/bbb.65.1412.


We investigated the effects of a buckwheat protein product (BWP), soy protein isolate (SPI) and casein on the plasma cholesterol level and fecal steroid excretion in rats fed on a cholesterol-free diet. The consumption of BWP suppressed plasma cholesterol by enhancing the fecal excretion of both neutral and acidic steroids. These effects of BWP were stronger than those of SPI.

MeSH terms

  • Animals
  • Anticholesteremic Agents / pharmacology*
  • Cholesterol / blood*
  • Cholesterol, Dietary / metabolism
  • Diet
  • Eating / drug effects
  • Fagopyrum / chemistry*
  • Feces / chemistry*
  • Male
  • Plant Proteins / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Soybean Proteins / pharmacology*
  • Steroids / metabolism*
  • Weight Gain / drug effects


  • Anticholesteremic Agents
  • Cholesterol, Dietary
  • Plant Proteins
  • Soybean Proteins
  • Steroids
  • Cholesterol