Pulmonary hemorrhage in association with negative pressure edema in an intubated patient

Acta Anaesthesiol Scand. 2001 Aug;45(7):911-3. doi: 10.1034/j.1399-6576.2001.045007911.x.


Negative pressure pulmonary edema due to upper airway obstruction following extubation is a well-recognized problem. However, frank pulmonary hemorrhage as a manifestation of upper airway obstruction is uncommon. We report a case of significant pulmonary hemorrhage and negative pressure pulmonary edema in an intubated patient. Bronchoscopy showed a collection of blood in the right lower lobe of the lungs, suggesting a localized source of bleeding. There have been two previously reported cases of pulmonary hemorrhage after upper airway obstruction. One suggested that the bleeding was due to damage to the pulmonary capillaries, the other that it was due to disruption of the bronchial vessels. We feel that in our case there was some indication that the pulmonary bleeding was a result of bronchial vessel damage. A number of factors might have been involved in its development, including negative pulmonary pressure, recent respiratory tract infection, and positive airways pressure (due to coughing).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Airway Obstruction / etiology*
  • Anesthesia, General
  • Blood Gas Analysis
  • Diuretics / therapeutic use
  • Furosemide / therapeutic use
  • Hemorrhage / physiopathology*
  • Hernia, Inguinal / surgery
  • Humans
  • Intubation, Intratracheal / adverse effects*
  • Lung Diseases / complications
  • Lung Diseases / physiopathology*
  • Male
  • Oxygen / blood
  • Pulmonary Edema / complications
  • Pulmonary Edema / physiopathology*


  • Diuretics
  • Furosemide
  • Oxygen