There are some benefits for eradicating Helicobacter pylori in patients with non-ulcer dyspepsia

Aliment Pharmacol Ther. 2001 Aug;15(8):1177-85. doi: 10.1046/j.1365-2036.2001.01014.x.


Background: The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is not established.

Aim: To determine whether eradication of H. pylori might be of benefit in non-ulcer dyspepsia patients.

Methods: We randomly assigned 129 H. pylori infected patients with severe epigastric pain, without gastro-oesophageal reflux symptoms, to receive twice daily treatment with 300 mg of ranitidine, 1000 mg of amoxicillin, and 500 mg of clarithromycin for 7 days and 124 such patients to receive identical-appearing placebos.

Results: Treatment was successful (decrease of symptoms at 12 months) in 62% of patients in the active-treatment group and in 60% of the placebo group (N.S.). At 12 months, the rate of eradication of H. pylori was 69% in the active-treatment group and 18% in the placebo group (P < 0.001). Complete relief of symptoms occurred significantly more frequently in patients on the active treatment (43%) than in placebo-treated patients (31%, P=0.048). Within the active-treatment group, therapeutic success was significantly more frequent in the non-infected patients (84% vs. 64%, P=0.04).

Conclusions: Although eradicating H. pylori is not likely to relieve symptoms in the majority of patients with non-ulcer dyspepsia, a small proportion of H. pylori-infected patients may benefit from eradication treatment.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amoxicillin / therapeutic use*
  • Anti-Bacterial Agents / therapeutic use*
  • Anti-Ulcer Agents / therapeutic use
  • Clarithromycin / therapeutic use*
  • Drug Therapy, Combination
  • Dyspepsia / drug therapy*
  • Dyspepsia / microbiology
  • Gastritis / drug therapy
  • Gastritis / microbiology
  • Helicobacter Infections / complications
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori* / cytology
  • Helicobacter pylori* / isolation & purification
  • Humans
  • Middle Aged
  • Pain Measurement
  • Penicillins / therapeutic use*
  • Quality of Life
  • Ranitidine / therapeutic use
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Anti-Ulcer Agents
  • Penicillins
  • Amoxicillin
  • Ranitidine
  • Clarithromycin