Selective expression of angiopoietin 1 and 2 in mesenchymal cells surrounding veins and arteries of the avian embryo

Mech Dev. 2001 Aug;106(1-2):133-6. doi: 10.1016/s0925-4773(01)00425-7.

Abstract

The expression of angiopoietin1 and 2 (ang1 and 2) and their receptor tie-2 was studied in avian embryos using in situ hybridization. Ang1 was transcribed in the mesenchymal cells surrounding venous endothelium expressing tie-2. By contrast, ang2 was transcribed around arteries in which the endothelium down-regulated tie-2 mRNA. The aorta and large arteries of the heart outflow tract were never surrounded by ang2 positive cells and maintained tie-2 expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiopoietin-1
  • Angiopoietin-2
  • Animals
  • Aorta / embryology
  • Aorta / metabolism
  • Arteries / embryology*
  • Chick Embryo
  • Down-Regulation
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / embryology
  • Endothelium, Vascular / metabolism
  • Gene Expression Regulation, Developmental*
  • Heart / embryology
  • In Situ Hybridization
  • Lymphatic System / embryology
  • Membrane Glycoproteins / genetics*
  • Mesoderm / cytology
  • Mesoderm / metabolism*
  • Neoplasm Proteins / genetics
  • Proteins / genetics*
  • Proteins / metabolism
  • Proto-Oncogene Proteins*
  • Quail / embryology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptor, TIE-2
  • Veins / embryology*

Substances

  • Angiopoietin-1
  • Angiopoietin-2
  • MEN1 protein, human
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Proteins
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Receptor, TIE-2