Novel cytotoxic annonaceous acetogenins from Annona muricata

J Nat Prod. 2001 Jul;64(7):925-31. doi: 10.1021/np010035s.

Abstract

Seven new annonaceous acetogenins, muricins A-G (1-7), as well as five known compounds, a mixture of muricatetrocin A (8) and muricatetrocin B (9), longifolicin (10), corossolin (11), and corossolone (12), were isolated from the seeds of Annona muricata. The structures of all isolates were elucidated and characterized by spectral and chemical methods. These acetogenins showed significantly selective in vitro cytotoxicities toward the human hepatoma cell lines Hep G(2) and 2,2,15.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Carcinoma, Hepatocellular / metabolism
  • Furans / chemistry
  • Furans / isolation & purification*
  • Furans / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Seeds / chemistry
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Taiwan
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents, Phytogenic
  • Furans