Suberedamines A and B, new bromotyrosine alkaloids from a sponge Suberea species

J Nat Prod. 2001 Jul;64(7):980-2. doi: 10.1021/np010077g.

Abstract

Two new cytotoxic bromotyrosine alkaloids, suberedamines A (1) and B (2), have been isolated from an Okinawan marine sponge Suberea sp. The structures were elucidated on the basis of spectroscopic data and chemical means.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Chromatography, High Pressure Liquid
  • Japan
  • Magnetic Resonance Spectroscopy
  • Mice
  • Micrococcus / drug effects
  • Molecular Structure
  • Porifera / chemistry*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured / drug effects
  • Tyrosine / analogs & derivatives
  • Tyrosine / chemistry
  • Tyrosine / isolation & purification*
  • Tyrosine / pharmacology

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • suberedamine A
  • suberedamine B
  • Tyrosine