Abstract
Two new cytotoxic bromotyrosine alkaloids, suberedamines A (1) and B (2), have been isolated from an Okinawan marine sponge Suberea sp. The structures were elucidated on the basis of spectroscopic data and chemical means.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Chromatography, High Pressure Liquid
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Japan
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Magnetic Resonance Spectroscopy
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Mice
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Micrococcus / drug effects
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Molecular Structure
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Porifera / chemistry*
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Structure-Activity Relationship
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Tumor Cells, Cultured / drug effects
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Tyrosine / analogs & derivatives
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Tyrosine / chemistry
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Tyrosine / isolation & purification*
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Tyrosine / pharmacology
Substances
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Alkaloids
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Anti-Bacterial Agents
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Antineoplastic Agents
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suberedamine A
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suberedamine B
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Tyrosine