Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation

J Nat Prod. 2001 Jul;64(7):993-6. doi: 10.1021/np000592z.

Abstract

A mixture of 6-O-acyl-beta-D-glucosyl-beta-sitosterols, the acyl moeity being primarily palmitoyl and linoleyl with minor amounts of stearyl and oleyl, has been isolated as a potent cytotoxic agent from fig (Ficuscarica) latex and soybeans. Identity was established by spectroscopic methods (NMR, MS) and confirmed by chemical synthesis. Both the natural and the synthetic compounds showed in vitro inhibitory effects on proliferation of various cancer cell lines.

Publication types

  • Comparative Study

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Female
  • Fruit / chemistry*
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • Humans
  • Latex / chemistry
  • Latex / isolation & purification*
  • Latex / pharmacology
  • Leukemia
  • Lymphoma
  • Magnetic Resonance Spectroscopy
  • Male
  • Mammary Neoplasms, Animal
  • Mass Spectrometry
  • Plants, Medicinal / chemistry*
  • Prostatic Neoplasms
  • Sitosterols / chemistry
  • Sitosterols / isolation & purification*
  • Sitosterols / pharmacology
  • Soybeans / chemistry*
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents, Phytogenic
  • Glucosides
  • Latex
  • Sitosterols