Since a dialysis patient in Austria still waits on average more than two years for a renal transplant, the question of a transplant from a living donor is very interesting. We differentiate between related and non-related living donors, who are chosen on the basis of medical criteria and emotional ties. Austria's first three kidney transplants from related donors were performed in 1967. Since then a total of 317 kidneys from genetically related donors have been transplanted until December 31, 2000. Transplants from non-related living donors were performed once in 1982, once in 1990 and since 1995 in a steadily increasing number each year, until they reached 47 by December 31, 2000. The United Network for Organ Sharing calculated the ten-year survival rate for functional grafts for a four-year period (1995-1998) in more than 30,000 renal transplant recipients from HLA-identical twins, non-related living donors, parent and cadaver donors. As anticipated, this study demonstrates that HLA-identical twins (n = 1,581) have the most functional grafts (81%), followed by non-related donor-recipients (n = 1,704) at 67% despite their often poor HLA match, parent-child transplants (n = 2,428) at 62% and cadaver renal grafts (n = 26,178) at 50%. Therefore, medical aspects as well as influences from the psychosocial environment would appear to be decisive for transplantation success. Thus, when choosing from several possible living donors it is absolutely justifiable to choose a donor with a poorer HLA match but good emotional ties. Such a choice requires strict selection criteria, and surgical preparation and follow-up demand the greatest care. While the criteria given in this paper are meant to be guidelines to help in deciding for a liver donor, they certainly do not rule out a different approach following critical reflection and participation by the affected parties, namely donor and recipient, as well as their advisors, nephrologist, transplant surgeon and psychotherapist. At the same time we need to make every effort to further intensify the use of cadaver kidneys. Only in this way can we ensure optimal implementation of all the resources available to us for supplying renal grafts to dialysis patients.