Interactions of carbenicillin and ticarcillin with gentamicin

Antimicrob Agents Chemother. 1975 Apr;7(4):431-4. doi: 10.1128/AAC.7.4.431.

Abstract

The in vitro inactivation of gentamicin by carbenicillin and a new semisynthetic penicillin, ticarcillin (BRL 2288), has been demonstrated. Gentamicin half-lives have been studied in eight patients with end-stage renal failure, and a 25 to 74% reduction in half-life has resulted from the concomitant administration of therapeutic doses of carbenicillin and ticarcillin.

MeSH terms

  • Carbenicillin / pharmacology*
  • Dialysis
  • Drug Interactions
  • Gentamicins / antagonists & inhibitors
  • Gentamicins / pharmacology*
  • Half-Life
  • Humans
  • Penicillins / pharmacology*
  • Ticarcillin / pharmacology*

Substances

  • Gentamicins
  • Penicillins
  • Ticarcillin
  • Carbenicillin