Regulation of Na+ channel distribution in the nervous system

Trends Neurosci. 2001 Aug;24(8):473-8. doi: 10.1016/s0166-2236(00)01884-1.


An important aspect of Na+ channel regulation is their distribution on neuronal membranes within the nervous system. The complexity of this process is brought by the molecular diversity of Na+ channels and differential regulation of their distribution. In addition, Na+ channel localization is a highly dynamic process depending on the status of the cell in vitro, and (patho)physiological condition of the organism in vivo. Nonetheless, the pharmacological manipulation of Na+ channel distribution should be possible and will hopefully bring safer and more-potent medicines in the future.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain Chemistry / physiology*
  • Nervous System / metabolism*
  • Sodium Channels / analysis*
  • Sodium Channels / metabolism*


  • Sodium Channels