Energy cost of physical activity in cystic fibrosis

Eur J Clin Nutr. 2001 Aug;55(8):690-7. doi: 10.1038/sj.ejcn.1601201.

Abstract

Objective: The purpose of this study was to compare the energy cost of standardized physical activity (ECA) between patients with cystic fibrosis (CF) and healthy control subjects.

Design: Cross-sectional study using patients with CF and volunteers from the community.

Setting: University laboratory.

Subjects: Fifteen patients (age 24.6+/-4.6 y) recruited with consent from their treating physician and 16 healthy control subjects (age 25.3+/-3.2) recruited via local advertisement.

Interventions: Patients and controls walked on a computerised treadmill at 1.5 km/h for 60 min followed by a 60 min recovery period and, on a second occasion, cycled at 0.5 kp (kilopond), 30 rpm followed by a 60 min recovery. The ECA was measured via indirect calorimetry. Resting energy expenditure (REE), nutritional status, pulmonary function and genotype were determined.

Results: The REE in patients was significantly greater than the REE measured in controls (P=0.03) and was not related to the severity of lung disease or genotype. There was a significant difference between groups when comparing the ECA for walking kg radical FFM (P=0.001) and cycling kg radical FFM (P=0.04). The ECA for each activity was adjusted (ECA(adj)) for the contribution of REE (ECA kJ kg radical FFM 120 min(-1)--REE kJ kg radical FFM 120 min(-1)). ECA(adj) revealed a significant difference between groups for the walking protocol (P=0.001) but no difference for the cycling protocol (P=0.45). This finding may be related to the fact that the work rate during walking was more highly regulated than during cycling.

Conclusions: ECA in CF is increased and is likely to be explained by an additional energy-requiring component related to the exercise itself and not an increased REE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anthropometry
  • Calorimetry, Indirect
  • Case-Control Studies
  • Cross-Sectional Studies
  • Cystic Fibrosis / metabolism*
  • Cystic Fibrosis / physiopathology
  • Energy Metabolism*
  • Exercise*
  • Female
  • Genotype
  • Humans
  • Male
  • Nutritional Status
  • Oxygen Consumption
  • Running
  • Walking