Molecular recognition by induced fit: how fit is the concept?

News Physiol Sci. 2001 Aug;16:171-3. doi: 10.1152/physiologyonline.2001.16.4.171.


Induced fit explains why biomolecules can bind together even if they are not optimized for binding. However, induced fit can lead to a kinetic bottleneck and does not describe every interaction in the absence of prior complementarity. Preselection of a fitting conformer is an alternative to induced fit.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigen-Antibody Complex / physiology
  • Biological Products / chemistry
  • Biological Products / metabolism*
  • Models, Biological*
  • Molecular Conformation


  • Antigen-Antibody Complex
  • Biological Products