Iron on the brain

Nat Genet. 2001 Aug;28(4):299-300. doi: 10.1038/91036.

Abstract

Accumulations of iron are often detected in the brains of people suffering from neurodegenerative diseases. But it is often not known whether such accumulations contribute directly to disease progression. The identification of the genes mutated in two such disorders suggests that errors in iron metabolism do indeed have a key role.

Publication types

  • Comment
  • News

MeSH terms

  • Animals
  • Axons / metabolism
  • Biological Transport
  • Brain / metabolism*
  • Cysteine / metabolism
  • Disease Progression
  • Ferritins / genetics*
  • Ferritins / metabolism
  • Humans
  • Iron / metabolism*
  • Iron-Regulatory Proteins
  • Iron-Sulfur Proteins / genetics*
  • Mice
  • Mutation
  • Neurodegenerative Diseases / etiology
  • Neurodegenerative Diseases / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / genetics
  • RNA-Binding Proteins / genetics*

Substances

  • Iron-Regulatory Proteins
  • Iron-Sulfur Proteins
  • RNA-Binding Proteins
  • Ferritins
  • Iron
  • Phosphotransferases (Alcohol Group Acceptor)
  • pantothenate kinase
  • Cysteine