Autoimmune disease: why and where it occurs

Nat Med. 2001 Aug;7(8):899-905. doi: 10.1038/90935.


Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overall reactivity of the immune system, the specific antigen and its presentation, and the target issue.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigens / immunology
  • Autoimmune Diseases / etiology*
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology
  • Chromosome Mapping
  • Cross Reactions
  • Humans
  • Models, Biological


  • Antigens