The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Nat Med. 2001 Aug;7(8):947-53. doi: 10.1038/90992.


Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adipocytes / metabolism*
  • Adiponectin
  • Animals
  • Blood Proteins / metabolism
  • Blood Proteins / physiology*
  • Cell Line
  • Energy Intake
  • Glucose / biosynthesis
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Insulin / physiology*
  • Intercellular Signaling Peptides and Proteins*
  • Liver / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Proteins*
  • Recombinant Proteins / metabolism
  • Thiazoles / pharmacology
  • Thiazolidinediones*


  • Adiponectin
  • Blood Proteins
  • Hypoglycemic Agents
  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Proteins
  • Recombinant Proteins
  • Thiazoles
  • Thiazolidinediones
  • 2,4-thiazolidinedione
  • Glucose