TPU-0031-A and B, new antibiotics of the novobiocin group produced by Streptomyces sp. TP-A0556
- PMID: 11480888
- DOI: 10.7164/antibiotics.54.441
TPU-0031-A and B, new antibiotics of the novobiocin group produced by Streptomyces sp. TP-A0556
Abstract
Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification. Spectroscopic analyses showed that TPU-0031-A and B were 7'-demethylnovobiocin and 5"-demethylnovobiocin, respectively. These compounds showed antibiotic activity against Gram-positive and -negative bacteria.
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