Association of an interleukin-1beta genetic polymorphism with altered brain structure in patients with schizophrenia

Am J Psychiatry. 2001 Aug;158(8):1316-9. doi: 10.1176/appi.ajp.158.8.1316.


Objective: This study investigated the effect on brain morphology of an interleukin-1beta genetic polymorphism (C-->T transition at position -511) in patients with schizophrenia.

Method: In vivo magnetic resonance imaging and genotype analysis were used in the examination of 44 male schizophrenic patients and 48 healthy male comparison subjects.

Results: No association between the interleukin-1beta polymorphism and schizophrenia was detected. Within the patient group, bifrontal-temporal gray matter volume deficits and generalized white matter tissue deficits in allele 2 carriers (genotype T/T or C/T) were found. In contrast, the interleukin-1beta polymorphism had no influence on brain morphology within the healthy subjects.

Conclusions: The data suggest that allele 2 within the promoter region of the interleukin-1beta gene at position -511 contributes to structural brain alterations in patients with schizophrenia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain / anatomy & histology*
  • Gene Frequency
  • Genotype
  • Humans
  • Interleukin-1 / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Schizophrenia / diagnosis*
  • Schizophrenia / genetics


  • Interleukin-1