Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice

FASEB J. 2001 Aug;15(10):1840-2. doi: 10.1096/fj.00-0750fje.

Authors

K Schäfer¹, K Fujisawa, S Konstantinides, D J Loskutoff

Affiliation

¹ Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

PMID: 11481248
DOI: 10.1096/fj.00-0750fje

No abstract available

MeSH terms

Adipose Tissue* / metabolism
Animals
Body Composition*
Diabetes Mellitus / metabolism*
Gene Expression
Hyperglycemia / etiology
Hyperglycemia / prevention & control
Hyperinsulinism / etiology
Hyperinsulinism / prevention & control
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Obese
Obesity / complications
Obesity / metabolism*
Plasminogen Activator Inhibitor 1 / deficiency*
Plasminogen Activator Inhibitor 1 / genetics*
Plasminogen Activator Inhibitor 1 / physiology
Tumor Necrosis Factor-alpha / genetics

Substances

Plasminogen Activator Inhibitor 1
Tumor Necrosis Factor-alpha