Treatment of neuroleptic malignant syndrome with subcutaneous apomorphine monotherapy

Mov Disord. 2001 Jul;16(4):765-7. doi: 10.1002/mds.1133.

Abstract

A 20-year-old psychiatric patient receiving haloperidol treatment developed acute-onset fever, rigidity, and mental changes. Subcutaneous apomorphine was given alone for treatment. The patient had rapid clinical improvement after the treatment. Serial blood examinations showed decline and subsequent normalization of the creatine phosphokinase levels.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Apomorphine / administration & dosage*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Haloperidol / administration & dosage
  • Haloperidol / adverse effects
  • Humans
  • Injections, Subcutaneous
  • Neuroleptic Malignant Syndrome / drug therapy*
  • Neurologic Examination / drug effects
  • Schizophrenia / drug therapy
  • Trihexyphenidyl / administration & dosage
  • Trihexyphenidyl / adverse effects

Substances

  • Trihexyphenidyl
  • Haloperidol
  • Apomorphine