Hemoglobin-A2-Coburg or alpha2delta2116Arg leads to His (G18)

Biochim Biophys Acta. 1975 Jun 26;393(2):379-82. doi: 10.1016/0005-2795(75)90065-3.

Abstract

Hemoglobin-A2-Coburg or alpha2delta2-116 Arg leads to His (G18) has been found in members of a family of Sicilian origin. The propositus is heterozygous for hemoglobin-A2-Coburg as well as for beta-thalassemia, and family data indicate that the gene for the delta-Coburg chain is in trans of the beta-thalassemia determinant.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Amino Acids / analysis
  • Chromatography
  • Diseases in Twins
  • Electrophoresis, Starch Gel
  • Female
  • Genes*
  • Hemoglobinopathies / blood
  • Hemoglobinopathies / genetics*
  • Hemoglobins / analysis
  • Hemoglobins, Abnormal / analysis*
  • Heterozygote
  • Homozygote
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Pedigree
  • Thalassemia / blood
  • Thalassemia / genetics
  • Trypsin

Substances

  • Amino Acids
  • Hemoglobins
  • Hemoglobins, Abnormal
  • Trypsin