Efficient proline-catalyzed Michael additions of unmodified ketones to nitro olefins

B List; P Pojarliev; H J Martin

doi:10.1021/ol015799d

Efficient proline-catalyzed Michael additions of unmodified ketones to nitro olefins

Org Lett. 2001 Aug 9;3(16):2423-5. doi: 10.1021/ol015799d.

Authors

B List¹, P Pojarliev, H J Martin

Affiliation

¹ Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. blist@scripps.edu

PMID: 11483025
DOI: 10.1021/ol015799d

Abstract

[reaction: see text] Here we describe the proline-catalyzed Michael addition of unmodified ketones to nitro olefins. This novel reaction provides gamma-nitro ketones in modest enantioselectivity yet excellent yields.