The origin of CDK regulation

Nat Cell Biol. 2001 Aug;3(8):E182-4. doi: 10.1038/35087119.

Abstract

The initiation of DNA replication is restrained by Cip/Kip proteins that inhibit Cdk2. Degradation of Xenopus Xic1, a Kip1 orthologue, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and (subsequent initiation of replication) is co-ordinately regulated at, and localised to, replication origins.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / metabolism*
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclin-Dependent Kinases / metabolism*
  • Cyclins / metabolism
  • DNA Replication / physiology*
  • Humans
  • Peptide Synthases / metabolism
  • SKP Cullin F-Box Protein Ligases
  • Signal Transduction / physiology*
  • Tumor Suppressor Proteins*

Substances

  • CDKN1A protein, human
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Tumor Suppressor Proteins
  • Cyclin-Dependent Kinase Inhibitor p27
  • SKP Cullin F-Box Protein Ligases
  • Cyclin-Dependent Kinases
  • Peptide Synthases