Mycobacterium Tuberculosis: Here Today, and Here Tomorrow

Nat Rev Mol Cell Biol. 2001 Aug;2(8):569-77. doi: 10.1038/35085034.

Abstract

Mycobacterium tuberculosis is a highly successful pathogen that parasitizes the macrophages of its host. Its success can be attributed directly to its ability to manipulate the phagosome that it resides in and to prevent the normal maturation of this organelle into an acidic, hydrolytic compartment. As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Antitubercular Agents / therapeutic use
  • BCG Vaccine
  • Calmodulin / physiology
  • Carrier Proteins / physiology
  • Cation Transport Proteins*
  • Cations / metabolism
  • Child
  • Drug Design
  • Endosomes / microbiology
  • Endosomes / physiology
  • HLA-D Antigens / immunology
  • Humans
  • Hydrogen-Ion Concentration
  • Intracellular Membranes / physiology
  • Ion Transport
  • Isocitrate Lyase / deficiency
  • Isocitrate Lyase / genetics
  • Isocitrate Lyase / physiology
  • Lipids / physiology
  • Lysosomes / chemistry
  • Macrophages, Alveolar / enzymology
  • Macrophages, Alveolar / microbiology*
  • Macrophages, Alveolar / ultrastructure
  • Membrane Fusion
  • Membrane Proteins / physiology
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Mycobacterium avium / physiology
  • Mycobacterium avium-intracellulare Infection / immunology
  • Mycobacterium avium-intracellulare Infection / microbiology
  • Mycobacterium avium-intracellulare Infection / pathology
  • Mycobacterium bovis / physiology
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / physiology*
  • Phagosomes / microbiology
  • Phagosomes / physiology
  • Transferrin / metabolism
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / immunology
  • Tuberculosis, Pulmonary / microbiology*
  • Tuberculosis, Pulmonary / pathology
  • Vacuoles / microbiology

Substances

  • Antitubercular Agents
  • BCG Vaccine
  • Calmodulin
  • Carrier Proteins
  • Cation Transport Proteins
  • Cations
  • HLA-D Antigens
  • Lipids
  • Membrane Proteins
  • Transferrin
  • natural resistance-associated macrophage protein 1
  • phthiocerol dimycocerosate
  • Isocitrate Lyase