The phosphatidylserine receptor: a crucial molecular switch?

Nat Rev Mol Cell Biol. 2001 Aug;2(8):627-33. doi: 10.1038/35085094.

Abstract

The uptake and removal of necrotic or lysed cells involves inflammation and an immune response, due in part to processes that involve members of the collectin family, surface calreticulin and CD91. Clearance of apoptotic cells, by contrast, does not induce either inflammation or immunity. Could the phosphatidylserine receptor be the molecular switch that determines what the outcome will be?

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Apoptosis / physiology
  • Calcium-Binding Proteins / physiology
  • Calreticulin
  • Carrier Proteins / physiology
  • Cell Adhesion
  • Cell Death / physiology*
  • Cellular Senescence
  • Collectins
  • Dendritic Cells / physiology
  • Endopeptidases / physiology
  • Humans
  • Inflammation
  • Inflammation Mediators / metabolism
  • Jumonji Domain-Containing Histone Demethylases
  • Low Density Lipoprotein Receptor-Related Protein-1
  • Membrane Lipids / physiology
  • Models, Biological
  • Necrosis
  • Phagocytosis / physiology
  • Phosphatidylserines / physiology
  • Receptors, Cell Surface / physiology*
  • Receptors, Immunologic / physiology
  • Ribonucleoproteins / physiology
  • Transforming Growth Factor beta / physiology

Substances

  • Calcium-Binding Proteins
  • Calreticulin
  • Carrier Proteins
  • Collectins
  • Inflammation Mediators
  • Low Density Lipoprotein Receptor-Related Protein-1
  • Membrane Lipids
  • Phosphatidylserines
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • Ribonucleoproteins
  • Transforming Growth Factor beta
  • phosphatidylserine receptor
  • JMJD6 protein, human
  • Jumonji Domain-Containing Histone Demethylases
  • Endopeptidases