Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 19 (2), 152-71

Carvedilol: Molecular and Cellular Basis for Its Multifaceted Therapeutic Potential

Affiliations
Review

Carvedilol: Molecular and Cellular Basis for Its Multifaceted Therapeutic Potential

J Cheng et al. Cardiovasc Drug Rev.

Abstract

Carvedilol is a unique cardiovascular drug of multifaceted therapeutic potential. Its major molecular targets recognized to date are membrane adrenoceptors (beta 1, beta 2, and alpha 1), reactive oxygen species, and ion channels (K+ and Ca2+). Carvedilol provides prominent hemodynamic benefits mainly through a balanced adrenoceptor blockade, which causes a reduction in cardiac work in association with peripheral vasodilation. This drug assures remarkable cardiovascular protection through its antiproliferative/atherogenic, antiischemic, antihypertrophic, and antiarrhythmic actions. These actions are a consequence of its potent antioxidant effects, amelioration of glucose/lipid metabolism, modulation of neurohumoral factors, and modulation of cardiac electrophysiologic properties. The usefulness of carvedilol in the treatment of hypertension, ischemic heart disease, and congestive heart failure is based on a combination of hemodynamic benefits and cardiovascular protection.

Similar articles

See all similar articles

Cited by 13 PubMed Central articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback