Smooth muscle cell depletion and collagen types in progeric arteries

Cardiovasc Pathol. May-Jun 2001;10(3):133-6. doi: 10.1016/s1054-8807(01)00069-2.

Abstract

Review of two autopsy cases of progeria confirms severe smooth muscle cell (SMC) depletion in the atherosclerotic aortic media and the presence of collagen types I, III, IV, V, and VI in the aorta and renal vessels as is consistent with atherosclerotic disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aorta / metabolism
  • Aorta / pathology
  • Arteriosclerosis / etiology
  • Arteriosclerosis / metabolism
  • Arteriosclerosis / pathology
  • Blood Vessels / metabolism
  • Blood Vessels / pathology
  • Child
  • Collagen / classification
  • Collagen / metabolism*
  • Fatal Outcome
  • Female
  • Humans
  • Male
  • Muscle, Smooth, Vascular / metabolism*
  • Muscle, Smooth, Vascular / pathology*
  • Progeria / complications
  • Progeria / metabolism*
  • Progeria / pathology*
  • Reference Values
  • Renal Circulation

Substances

  • Collagen