A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease

Nature. 1986 Oct 23;323(6090):688-92. doi: 10.1038/323688a0.


The maternal effect gene snake is required for the establishment of the dorsal-ventral axis during the embryonic development of Drosophila. The molecular cloning of the gene and analysis of a complementary DNA sequence suggest that the gene encodes a serine protease which is structurally similar to proteases involved in blood clotting, peptide processing, and complement fixation pathways.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / growth & development*
  • Female
  • Genes, Insect
  • Molecular Sequence Data
  • Serine Endopeptidases / isolation & purification
  • Serine Endopeptidases / physiology*
  • Transcription Factors / isolation & purification
  • Transcription Factors / physiology*


  • Transcription Factors
  • Serine Endopeptidases