Leiomyosarcoma of the bladder fourteen years after cyclophosphamide therapy for retinoblastoma

Scand J Urol Nephrol. 2001 Jun;35(3):248-9. doi: 10.1080/003655901750292060.


We report a case of bladder leiomyosarcoma which occurred in a 22-year-old female who had been treated with cyclophosphamide for a period of 68 months for retinoblastoma diagnosed at 18 months postpartum. Partial cystectomy was performed. Forty-two months after the operation she is tumor-free.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Cyclophosphamide / adverse effects*
  • Female
  • Humans
  • Infant
  • Leiomyosarcoma / chemically induced*
  • Retinal Neoplasms / drug therapy*
  • Retinoblastoma / drug therapy*
  • Time Factors
  • Urinary Bladder Neoplasms / chemically induced*


  • Cyclophosphamide