CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation

Br J Cancer. 2001 Aug 3;85(3):422-7. doi: 10.1054/bjoc.2001.1869.


2-18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / metabolism
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology*
  • Carcinoma, Basal Cell / metabolism
  • Carcinoma, Basal Cell / pathology*
  • Carcinoma, Ductal, Breast / metabolism
  • Carcinoma, Ductal, Breast / pathology*
  • Cell Differentiation
  • Humans
  • Immunoenzyme Techniques
  • Keratins / metabolism
  • Male
  • Middle Aged
  • Myoepithelioma / metabolism
  • Myoepithelioma / pathology*
  • Neoplasm Proteins / metabolism
  • Neoplasm Staging
  • Nucleic Acid Hybridization
  • Prognosis


  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Keratins