Randomized comparison of long-term losartan versus propranolol in lowering portal pressure in cirrhosis

Gastroenterology. 2001 Aug;121(2):382-8. doi: 10.1053/gast.2001.26288.


Background & aims: It has been suggested that losartan, an angiotensin II (A-II) type 1 receptor blocker, may have a pronounced portal pressure reducing effect, far greater than that of propranolol. This randomized controlled trial compared the hemodynamic and renal effects of continued 6-week administration of losartan (n = 25) vs. propranolol (n = 15) in portal hypertensive patients with cirrhosis treated endoscopically after a variceal bleeding episode.

Methods: Hepatic venous pressure gradient (HVPG), systemic hemodynamics, renal function, and vasoactive factors were measured before and at 6 weeks of treatment.

Results: Losartan did not reduce HVPG (-2% +/- 12%, NS) but significantly decreased mean arterial pressure (MAP, -8% +/- 10%, P = 0.001). On the contrary, propranolol significantly reduced HVPG (-10% +/- 11%, P = 0.003) and cardiac output (-16% +/- 12%, P = 0.001) but did not modify MAP (2.5% +/- 10%, NS). Losartan increased A-II levels, reduced aldosterone, and decreased glomerular filtration rate (GFR) in Child B patients. Propranolol did not modify renal function. Adverse events related to therapy were mild and similar in both groups.

Conclusions: Unlike propranolol, long-term losartan administration does not significantly reduce HVPG in patients with cirrhosis treated after a variceal bleeding episode, and it caused hypotension and reduced GFR in patients with moderate liver failure. Therefore, losartan is not an alternative to propranolol in preventing variceal rebleeding.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antihypertensive Agents / administration & dosage*
  • Antihypertensive Agents / adverse effects
  • Blood Pressure / drug effects
  • Blood Urea Nitrogen
  • Creatinine / blood
  • Female
  • Glomerular Filtration Rate / drug effects
  • Humans
  • Hypertension, Portal / drug therapy*
  • Liver Circulation / drug effects
  • Liver Cirrhosis / complications*
  • Losartan / administration & dosage*
  • Losartan / adverse effects
  • Male
  • Middle Aged
  • Propranolol / administration & dosage*
  • Propranolol / adverse effects
  • Splanchnic Circulation / drug effects


  • Antihypertensive Agents
  • Propranolol
  • Creatinine
  • Losartan