Transient prevention of ethanol-induced gastric lesion by capsaicin due to release of endogenous calcitonin gene-related peptide in rats

Jpn J Pharmacol. 2001 Jul;86(3):351-4. doi: 10.1254/jjp.86.351.


Pre-exposure of the rat gastric mucosa to capsaicin reduced the mucosal lesion by 50% ethanol to 1/4. Treatment with an antagonist of calcitonin gene-related peptide (CGRP), CGRP (8-37), nullified the effect of capsaicin. During constant perfusion of the gastric lumen with physiological saline + pepstatin, the CGRP level was not increased by 50% ethanol, but it showed a peak (802.5 +/- 145.7 pg/2 min) after 1.6 mM capsaicin. Four minutes after capsaicin, the CGRP level was kept at a high level and the gastric lesion was markedly reduced by re-exposure of the mucosa to 50% ethanol. At 20-30 min after capsaicin, the CGRP levels returned to the resting level and the reddened area by 50% ethanol was not reduced. It was concluded that capsaicin transiently prevented the mucosal lesion through CGRP release.

MeSH terms

  • Animals
  • Calcitonin Gene-Related Peptide / metabolism*
  • Capsaicin / pharmacology*
  • Ethanol / pharmacology*
  • Gastric Mucosa / drug effects
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Stomach Ulcer / prevention & control*


  • Ethanol
  • Calcitonin Gene-Related Peptide
  • Capsaicin