Post-ischemic hypothermia blocks caspase-3 activation in the newborn rat brain after hypoxia-ischemia

Brain Res. 2001 Aug 10;910(1-2):187-91. doi: 10.1016/s0006-8993(01)02659-2.

Abstract

The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of caspase-3 activation may be an interventional point underlying the neuroprotective effect of hypothermia in neonates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn / metabolism*
  • Apoptosis / physiology
  • Body Temperature / physiology*
  • Brain / enzymology*
  • Brain / pathology
  • Brain / physiopathology
  • Caspase 3
  • Caspases / metabolism*
  • Disease Models, Animal
  • Hypothermia, Induced*
  • Hypoxia-Ischemia, Brain / enzymology*
  • Hypoxia-Ischemia, Brain / physiopathology
  • Hypoxia-Ischemia, Brain / therapy
  • Immunohistochemistry
  • Microtubule-Associated Proteins / metabolism
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Microtubule-Associated Proteins
  • Casp3 protein, rat
  • Caspase 3
  • Caspases