Clathrin-binding Proteins: Got a Motif? Join the Network!

Trends Cell Biol. 2001 Aug;11(8):315-8. doi: 10.1016/s0962-8924(01)02043-8.


Clathrin plays a key function in membrane and protein trafficking through the endocytic and late secretory pathways. Its role as a molecular scaffold that drives formation of transport vesicles requires binding to a number of proteins with distinct functional and structural properties. Recent studies have revealed that most of these proteins interact with clathrin through surprisingly simple, linear arrangements of acidic and hydrophobic amino acid residues. This article discusses the different types of clathrin-binding proteins and motifs as well as the physiological significance of these proteins in clathrin-dependent events.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Carrier Proteins / metabolism*
  • Clathrin / metabolism
  • HSC70 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins*
  • Ligands


  • Carrier Proteins
  • Clathrin
  • HSC70 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins
  • Ligands