The Health Utilities Index (HUI) system for assessing health-related quality of life in clinical studies

Ann Med. 2001 Jul;33(5):375-84. doi: 10.3109/07853890109002092.


This paper reviews the Health Utilities Index (HUI) systems as means to describe health status and obtain utility scores reflecting health-related quality of life (HRQoL). The HUI Mark 2 (HUI2) and Mark 3 (HUI3) classification and scoring systems are described. The methods used to estimate multiattribute utility functions for HUI2 and HUI3 are reviewed. The use of HUI in clinical studies for a wide variety of conditions in a large number of countries is illustrated. HUI provides a comprehensive description of the health status of subjects in clinical studies. HUI has been shown to be a reliable, responsive and valid measure in a wide variety of clinical studies. Utility scores provide an overall assessment of the HRQoL of patients. Utility scores are also useful in cost-utility analyses and related studies. General population norm data are available. The widespread use of HUI facilitates the interpretation of results and permits comparisons. HUI is a useful tool for assessing health status and HRQoL in clinical studies.

Publication types

  • Review

MeSH terms

  • Cost-Benefit Analysis
  • Cross-Sectional Studies
  • Health Status*
  • Humans
  • Longitudinal Studies
  • Outcome Assessment, Health Care
  • Quality of Life*
  • Randomized Controlled Trials as Topic
  • Reference Standards