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, 15 (4), 553-62

Epidemiology of Primary Sclerosing Cholangitis


Epidemiology of Primary Sclerosing Cholangitis

E Schrumpf et al. Best Pract Res Clin Gastroenterol.


Many patients suffering from primary sclerosing cholangitis (PSC) have no symptoms--or rather unspecific symptoms. Most patients have a cholestatic biochemical profile, but a specific blood test for the diagnosis of PSC is lacking. The diagnostic test (endoscopic retrograde cholangiography (ERC)) is an invasive procedure with potential complications. Also, in some patients the diagnosis of PSC is not easy, even when ERC has been performed. Therefore true incidence and prevalence data on PSC are extremely few. Nevertheless, it seems well established that the epidemiology of PSC is not the same all over the world. PSC is most often seen in Northern Europe. In this part of the world PSC is also associated with inflammatory bowel disease in most cases--and in the Nordic Countries PSC has become the primary indication for hepatic transplantation.

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