Lupus erythematosus/lichen planus overlap syndrome with scarring alopecia

J Eur Acad Dermatol Venereol. 2001 Mar;15(2):171-4. doi: 10.1046/j.1468-3083.2001.00223.x.


Lupus erythematosus (LE) and lichen planus (LP) may occur as an overlap syndrome (LE/LP). The term comprises a heterogeneous group of patients who have clinical, histological and/or immunopathological characteristics of both diseases at the same time. The disease occurs so infrequently as to limit clinical cases for study. We present a case of scarring alopecia due to LE/LP overlap syndrome. Initial biopsy of the scalp showed scarring alopecia only, with subsequent biopsies showing histological features of LE. Direct immunofluorescence was negative for the LE band, but showed features consistent with LP. We report this case as an uncommon cause of scarring alopecia illustrating the importance of multiple biopsies in the diagnosis of LE/LP overlap syndrome.

Publication types

  • Case Reports

MeSH terms

  • Alopecia / etiology
  • Alopecia / pathology*
  • Biopsy, Needle
  • Cicatrix / etiology
  • Cicatrix / pathology*
  • Female
  • Follow-Up Studies
  • Humans
  • Lichen Planus / complications
  • Lichen Planus / pathology*
  • Lupus Erythematosus, Cutaneous / complications
  • Lupus Erythematosus, Cutaneous / pathology*
  • Middle Aged
  • Syndrome