Evolving concepts in epithelial magnesium transport

Curr Opin Nephrol Hypertens. 2001 Sep;10(5):649-53. doi: 10.1097/00041552-200109000-00016.


Magnesium is an important, predominantly intracellular cation that is required for a wide variety of cellular processes. The mammalian kidney plays a key role in whole-body magnesium homeostasis, but the molecular and cellular mechanisms that underlie renal epithelial magnesium reabsorption are poorly understood. Traditional physiologic approaches have been severely hampered by the lack of a useful radioisotope of magnesium that can be used for tracer flux studies. The present review discusses physiologic insights gained from recent reverse-genetic studies that have identified a plethora of genes involved in inherited renal magnesium wasting syndromes.

Publication types

  • Editorial
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Epithelium / metabolism
  • Genes, Dominant
  • Humans
  • Kidney / metabolism*
  • Loop of Henle / metabolism
  • Magnesium / metabolism*
  • Magnesium Deficiency / genetics
  • Nephrology / trends*
  • Nephrons / metabolism


  • Magnesium