Plasma levels of diazepam after parenteral and rectal administration in children

Epilepsia. 1975 Jun;16(2):277-83. doi: 10.1111/j.1528-1157.1975.tb06058.x.


Plasma levels of diazepam and N-desmethyldiazepam were investigated in 19 children by a gas chromatographic method permitting the use of capillary sample. Intravenous administration was studied in 3 children and the plasma level curves showed a rapid decline during the first hour. Absorption and elimination after rectal administration of a solution in 16 children were similar to those after intramuscular administration. Diazepam given by suppository to 5 children gave much lower plasma levels and delayed time to peak levels. Recurrence of seizures in 2 children indicated that the anticonvulsants plasma level was of the order of 150 to 200 mug/liter. No significant side effects were observed. Thus rectal administration of a solution of diazepam is a practical method to arrest convulsions in children.

Publication types

  • Comparative Study

MeSH terms

  • Child
  • Child, Preschool
  • Chromatography, Gas
  • Diazepam / administration & dosage
  • Diazepam / analogs & derivatives
  • Diazepam / blood*
  • Diazepam / therapeutic use
  • Enema
  • Female
  • Humans
  • Infant
  • Injections, Intramuscular
  • Injections, Intravenous
  • Male
  • Seizures / drug therapy*
  • Suppositories
  • Time Factors


  • Suppositories
  • Diazepam