Aurintricarboxylic acid decreases proliferative potential of SKOV3 and MCF7 human carcinoma cells

V Fraifeld; R Seidman; O Sagi; K Muradian; M Wolfson

Aurintricarboxylic acid decreases proliferative potential of SKOV3 and MCF7 human carcinoma cells

Anticancer Res. 2001 May-Jun;21(3B):1975-8.

Authors

V Fraifeld¹, R Seidman, O Sagi, K Muradian, M Wolfson

Affiliation

¹ Department of Clinical Pharmacology, Center for the Multidisciplinary Research in Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel. vadimfra@zahav.net.il

PMID: 11497286

Abstract

The effect of aurintricarboxylic acid (ATA) on cell growth and proliferative capacity was studied in human ovarian SKOV3 and breast MCF7 carcinoma cells. ATA moderately inhibited cell growth measured by a Neutral red assay after a 24-hour incubation of the cells in the presence of ATA. The ATA-treated cells displayed a markedly decreased capacity to proliferate, as was evident from a colony formation assay. The initial and delayed anti-proliferative effects of ATA were dose-dependent. Together, the results indicated that ATA offers the potential of being recognized as an anti-tumor drug, at least in certain types of cancers.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antineoplastic Agents / pharmacology*
Aurintricarboxylic Acid / pharmacology*
Breast Neoplasms / drug therapy*
Breast Neoplasms / pathology*
Cell Division / drug effects
Cell Survival / drug effects
Dose-Response Relationship, Drug
Female
Humans
Ovarian Neoplasms / drug therapy*
Ovarian Neoplasms / pathology*
Time Factors
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Aurintricarboxylic Acid