Tethered-bilayer lipid membranes as a support for membrane-active peptides

Biochem Soc Trans. 2001 Aug;29(Pt 4):613-7. doi: 10.1042/bst0290613.

Abstract

An immunosensing device, comprising a lipid membrane incorporating ion channels tethered to the surface of a gold electrode, has been reported [Cornell, Braach-Maksvytis, King, Osman, Raguse, Wieczorek and Pace (1997) Nature (London) 387, 580-583]. The present article describes key steps in the assembly of the device and provides further evidence for its proposed sensing mechanism.

Publication types

  • Review

MeSH terms

  • Computer Simulation
  • Disulfides / chemistry
  • Electric Conductivity
  • Gramicidin
  • Lipid Bilayers / chemistry*
  • Membrane Lipids / chemistry
  • Models, Molecular
  • Molecular Conformation
  • Peptides / chemistry*
  • Structure-Activity Relationship

Substances

  • Disulfides
  • Lipid Bilayers
  • Membrane Lipids
  • Peptides
  • Gramicidin